OCTOBER 8-10, 2024

LISBON, PORTUGAL

9:00am - 9:20am

Feng Liu, Institute of Zoology (China)

Evolving paradigm for HSC biology

9:20pm - 9:35pm

Anastasia Nizhnik

Identifying the Origins of Innate Lymphoid Cells in Zebrafish Development

9:35am - 9:50am

Alessia Brix

ADA2 regulates inflammation and hematopoietic stem cells emergence via the A2bR pathway in zebrafish

9:50am - 10:05am

Lucy Copper

Exploring drivers of disease progression in a GATA2 deficiency zebrafish model

10:05am - 10:25am

J. Kimble Frazer

Dynamic Changes in Lymphocytes Establish Zebrafish as a Thymic Involution Model

10:25am - 10:40am

Flash Talks

• Stephan George Amyloid precursor protein negatively regulates endothelial to hematopoietic transition

• Sarada Ketharnathan Characterizing the role of KMT2C mutations in KMT2A-mediated rapid-onset infant leukemia

• Leonie Konopka Carboxy-terminal amino acids in the fibrinogen AalphaE chain are essential for fibrinogen-420 secretion

• Ondrej Svoboda Origins of primitive erythropoiesis in zebrafish

11:10am - 11:30am

11:30am - 11:45am

Duc Dong

The Extrahepatic Duct as a Novel Source of Liver Stem Cells

11:45am – 12:00pm

Ellie Meader

Bnip3lb-associated mitophagy regulates ROS-mediated depletion of the embryonic hematopoietic stem cell pool

12:00pm-12:15pm

Alissa Jackson

Extracellular Matrix Contributions to the Hematopoietic Stem Cell Specification

12:15pm - 12:30pm

12:30pm - 12:35pm

Flash Talks

• Danielle Woutersen Shp2 is essential for lymphangiogenesis during zebrafish development

• Shahad Albadri Redox signaling function during retinal progenitor cell differentiation

• JiWook Kim Identifying a novel mobilizing regimen for hematopoietic stem cell transplant

11:10am - 11:30am

Valerie Wittamer, Université Libre de Bruxelles (Belgium)

A mechanistic view of Tgf-beta-mediated microglia cell fate in vivo

11:30am - 11:45am

Margarida Gomes

Pro-inflammatory macrophages support trained neutrophils for host defence against Shigella infection

11:45am – 12:00pm

Fumihito Ono

A zebrafish gene with sequence similarities to human uromodulin and GP2 responds to bacterial exposure

12:00pm-12:15pm

Vincenzo Torraca

Shigella Serotypes Associated With Carriage in Humans Establish Persistent Infection in Zebrafish

12:15pm - 12:30pm

Annachiara Tesoriere

The role of P727 Stat3 regulation of vitamin D pathway in the pathogenesis of AD-HIES

12:30pm - 12:35pm

Flash Talks

• Darlan Gusso Zebrafish larvae stimulated by bacteria to inflammasome activation through caspase analyses

• Kaylee Van Dijk Differential role of Tnfα homologues in zebrafish during infection and inflammation, with a special focus on Tnfb

• Hannah Wigget The impact of the type 1 IFN response on the developing zebrafish brain

2:30pm - 2:50pm

James Gagnon, University of Utah, (USA)

Make your own sunscreen

2:50pm - 3:05pm

Sarah Brivio

Endothelial mafa expression controls HSC expansion in the CHT niche.

3:05pm -3:20pm

Kevin Thiessen

Abnormal inflammatory response and immune repertoire leads to worse scarring outcomes in a zebrafish model of human orofacial clefting

3:20pm - 3:35pm

Bruna Costa

The zAvatar-test forecasts patient’s treatment outcome in colorectal cancer: a clinical study towards personalized medicine

3:35pm - 3:55pm

Flash Talks

• Raquel Lama López In vivo investigation of spring viremia of carp virus (SVCV) infection in zebrafish larvae used as a predictive model to understand the disease pathophysiology and for drug screening

• Iris Peters Modeling patient-specific GATA2 missense mutations in zebrafish to study progression towards MDS/AML

4:05pm - 4:25pm

Paula Alexandre (UK)

Microcephaly: understanding the underlying mechanisms that regulate CNS growth

4:25pm - 4:40pm

Elizabeth Davidson

Identifying convergent mechanisms of ASD utilizing a high-throughput behavioral screen

4:40pm - 4:55pm

Eric Samarut

THAP12 REGULATES BRAIN DEVELOPMENT, AND MUTATIONS ARE ASSOCIATED WITH EPILEPTIC ENCEPHALOPATHY

4:55pm - 5:10pm

Kazuhide Asakawa

Intrinsic autophagic flux enhancement is amplified by loss of TDP-43 function in ALS-vulnerable motor neurons

5:10pm - 5:25pm

Lesha Pretorius

Are gut and brain aetiological mechanisms in ASD-related co-morbidities linked?

5:25pm - 5:30pm

Flash Talks

• Beatriz Bernal-Bermúdez Zebrafish model of the rare disease X-linked Intellectual Developmental Disorder-98 (XLID98) for drug repurposing

• Kathryn Adamson Fishing for a FOXG1 syndrome cure: using zebrafish models to explore disease-modifying approaches

4:05pm - 4:25pm

Karina Yaniv (Israel)

Formation and malformations of blood and lymphatic vessels”

4:25pm - 4:40pm

Usua Oyarbide

Salvage pathways for cardiac and skeletal myopathies but not neutropenia in tafazzin-deficient zebrafish

4:40pm - 4:55pm

Steven Farber

Photoconvertible LipoTimer reporter allows for direct in vivo measurement of atherogenic lipoprotein kinetics

4:55pm - 5:10pm

Jacky Goetz

Endothelial calcium firing mediates extravasation of metastatic tumour cells

5:10pm - 5:25pm

Dorien Schepers

In vivo optical mapping of cardiac action potentials and calcium transients in a novel zebrafish model for cardiac arrhythmia

5:25pm - 5:30pm

Flash Talks

• Claudine Ruijmbeek Zebrafish genetic models as a diagnostic tool to unravel new genetic causes and molecular mechanisms of pediatric cardiomyopathy

• Cátia Rebelo de Almeida An angiogenesis-independent mechanism of action for anti-VEGFA therapies

• Ines Marques Altering collagen cross-linking through lysyl oxidase chemical inhibition affects zebrafish heart regeneration