OCTOBER 8-10, 2024

LISBON, PORTUGAL

10:15am - 10:35am

Richard White, University of Oxford, (UK)

Melanoma cell fate – from the inside and the outside

10:35am - 10:50am

Lasse Janson

Overcoming drug development challenges within immune-oncology with the zebrafish tumor xenograft (ZTX®) IO platform.

10:50am - 11:05am

Madeline Webb

Bile acid dysregulation induces TGR5-dependent cachexia in liver cancer

11:05am - 11:20am

James Allen

ALL SET: Identifying new collaborating oncogenic drivers in acute lymphoblastic leukemia

11:20am - 11:40am

Marina Mione

Neutrophils in the Uveal Melanoma microenvironment induce YAP activation through LTD4 signaling

11:40am - 12:00pm

Flash Talks

• Elena Vasileva - Characterizing the cell of origin of Ewing sarcoma

• Elizabeth Cao - Fate mapping the tumor microenvironment across anatomic space

• Rebecca Anderson - Tissue-specific Expression of the EWSR1::FLI1 Fusion Protein using the col2a1a Promotor Reveals a Novel Model of Ewing Sarcoma in the Zebrafish

• Julia Hatzold - Comparison of Matriptase-dependent epidermal pre-neoplasms in two different embryonic zebrafish models reveals unique signatures causative of malignancy and metastasis

2:00pm – 2:20pm

Nicholas Rohner, Stowers Institute (USA)

Metabolic Adaptation to Nutrient Limitation in Vertebrates

2:20pm - 2:35pm

Nikolay Ninov

Optogenetic interrogation of ?-cells in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by Vitamin B6 metabolism

2:35pm - 2:50pm

Yasuhito Shimada

Exploring Gut Bacteria with Anxiolytic Effects through the Gut-Brain Axis using Zebrafish

2:50pm - 3:05pm

Manjari Trivedi

Elucidating the role of macrophages and neutrophils in liver regeneration post-injury

3:05pm - 3:20pm

Wenbiao Chen

Overnutrition-induced beta cell death results from islet-innate immune cell cross-talks

3:20pm - 3:25pm

Flash Talks

• Cerys Bladen Identifying regulators of lysosomal biogenesis in a model of Birt-Hogg-Dubé syndrome        

• Madelyn Jackstadt Mapping interactions between gut bacteria and hepatic metabolism 

• Anges Hendriks Diving into Zellweger Spectrum Disorders: Zebrafish as a gateway to therapeutic innovation

2:00pm – 2:20pm

José Bessa, Institute for Health Research and Innovation, (Portugal)

The Cis-Regulatory Code in the Development of Pancreatic Diseases

2:20pm - 2:35pm

Fanny Nobilleau

RFC1, a gene involved in late-onset ataxia, regulates cerebellar neurogenesis in zebrafish

2:35pm - 2:50pm

2:50pm - 3:05pm

Francisco Juan Martinez Navarro

Unveiling the Noncanonical Functions of Telomerase RNA Component (TERC) in Inflammation Resolution and Bacterial Resistance

3:05pm - 3:20pm

Marco Antonio Campinho

Zebrafish modeling of the human rare disease Allan-Herndon-Dudley syndrome reveals impaired hindbrain vascularization

3:20pm - 3:25pm

Flash Talks

• Stephanie  MacMaster Genomic mechanisms that control the fate and potential of the melanocyte stem cells               

• Abrah Kahsay Unlocking the molecular signature of extraocular muscles: Insights into protection against Muscle

4:20pm – 4:40pm

Yi Feng, The University of Edinburgh, (UK)

Oncogenic RAS expressing preneoplastic cells drive pro-tumour neutrophil development

4:40pm - 4:55pm

4:55pm -5:10pm

Darryl Han

Host telomerase is required for resistance to Mycobacterium marinum infection

5:10pm - 5:25pm

5:25pm - 5:45pm

Phil Elks

Tribbles1 activates leukocytes to be host protective during in vivo mycobacterial infection

5:45pm – 6:05pm

Flash Talks

• Kathryn Wright Sept6 regulates the macrophage response to mycobacterial infection

• Emma Roux Unveiling human norovirus tropism for intestinal macrophages through single-cell transcriptional analysis

• Mark Naven Live Imaging the Wound Inflammatory Response and the Consequences of Disrupted Circadian Clocks