The 9th Zebrafish Disease Models Conference Agenda

Venue: Marina Bay Sands

10 Bayfront Ave. Singapore, 018956


4th October 2016, Tuesday



Session Title

12:00pm – 6:00pm Registration Open

Welcome Remarks

Philip Ingham, Vice President of ZDMS and Chair of ZDM9



James Amatruda, President of ZDMS


Opening Address

James Best, Dean, Lee Kong Chian School of Medicine

Session 1: Cancer 1

2:20pm Thomas Look, Dana Farber Cancer Institute, USA Molecular Pathogenesis and Drug Synergism in a Zebrafish Model of High Risk Neuroblastoma
2:40pm Shuning He, Dana Farber Cancer Institute, USA A zebrafish model of NF1- and PTEN-mutant melanomas that lack activating mutations of BRAF or NRAS
2:55pm Paul Martin, University of Bristol, United Kingdom Modelling cancer Inflammation and treatments including surgery and radiotherapy
3:15pm James Amatruda, UT Southwestern Medical Center, USA Expression of human CIC-DUX4 fusions in zebrafish recapitulates the spectrum of human CIC-rearranged cancers
3:30pm Leonard Zon, Children’s Hospital Boston, USA Neural crest progenitor identity is a key event in the initiation of melanoma and metastasis
3:50pm Refreshment Break
Session 2: Emerging Technologies
4:20pm Sabine Costagliola, ULB-IRIBHM, Belgium A CRISPR/Cas-based mutagenesis approach in zebrafish to delineate gene function underlying congenital hypothyroidism
4:35pm Christian Mosimann, University of Zurich, Switzerland Of crispant screens for congenital disease genes
4:50pm Farhad Imam, University of California, San Diego, USA Zebrafish at the Bedside: in vivo Validation of Human Disease Sequence Variants
5:05pm Flash Talks

Keynote Speaker:

Stuart Cook

Professor and Director, Programme in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School, Director, National Heart Research Institute of Singapore

Professor of Clinical and Molecular Cardiology, Imperial College London, United Kingdom

6:30pm Welcome Reception

 5th October 2016, Wednesday 

Time Session/Speaker Session Title
8:00am – 5:00pm Registration Open

Session 3: Muscle and Cardiac – Concurrent Session

9:00am Peter Currie, ARMI, Monash University, Australia Cell cycle arrest regulates clonal drift of muscle stem cells during growth.
9:20am Ching Ling Ellen Lien, Children’s Hospital Los Angeles, USA Zebrafish model to study congenital coronary anomalies
9:35am Rebecca Richardson, University of Bristol, United Kingdom Specific macrophage populations are required for adult zebrafish cardiac regeneration
9:50am Alasdair Wood, ARMI, Monash University, Australia Evaluating Integrin-b1 as a Therapeutic Target for MDC1a
10:05am Inken Gisela Huttner, Victor Chang Cardiac Research Institute, Australia Assessment of cardiac function in adult zebrafish using high frequency echocardiography: validation and standardization of a novel protocol
10:20am Flash Talks
10:40am Jeroen Bakkers, The Hubrecht Institute, Netherlands Spatially resolved transcriptomics to identify regulators of heart regeneration.

Session 4: Hematology – Concurrent Session

9:00am Trista E. North, Harvard Medical School, USA

Distinct Roles for Matrix Metalloproteinase 2 (MMP2) and

MMP9 in Embryonic Hematopoietic Stem Cell Production

9:20pm Yoonsung Lee, University of California, San Diego, USA FACT component Supt16h regulates transcription of Notch elements to specify hematopoietic stem cells
9:35am Julie Perlin, Boston Children’s Hospital, USA Using genome-wide RNA tomography to dissect the hematopoietic stem cell niche in zebrafish
9:50am Valerie Wittamer, Universite Libre de Bruxelles, Belgium Insights into the Cellular and Molecular Mechanisms of Microglia Ontogeny
10:05am Martina Konantz, University Hospital Basel, Switzerland Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence
10:20am Flash Talks
10:40am Jill de Jong, The University of Chicago, USA Genomic and functional diversity of antigen processing and presentation genes in zebrafish
11:00am Refreshment Break

Keynote Speaker:

John Mattick

Executive Director, The Garvan Institute of Medical Research, Australia

12:30pm Lunch and Poster Session 1

Session 5: GI and Metabolism – Concurrent Session

3:00pm Michael A. Pack, University of Pennsylvania, USA Variant redox and proteomic stress responses as risk factors for biliary disease
3:20pm Andrew Cox, Brigham and Women’s Hospital, Harvard Medical School, USA Yap regulates glucose uptake and the anabolic biosynthesis of nucleotides to support liver growth
3:35pm Yanmei Liu, Institute of Molecular Medicine, Peking University, China Glucose Activates Calcineurin/NFAT to Initiate and Drive the Heterogeneous Maturation of beta Cells In Vivo
3:50pm Wolfram Goessling, Harvard Medical School, USA Estrogen sensing in the liver by the G protein-coupled receptor GPER1 regulates PI3K/AKT and MTOR activity to control normal and malignant growth
4:05pm Shawn Burgess, National Human Genome Research Institute, USA Integrating Human Clinical Data, Exome Sequencing, and High-throughput Zebrafish Mutagenesis for the Study of Rare Genetic Diseases
4:20pm Kirsten Sadler Edepli, New York University Abu Dhabi, United Arab Emirates A potent cocktail: Arsenic synergizes with ethanol to cause liver disease in zebrafish
4:40pm Flash Talks

Session 6: Infection and Immunity – Concurrent Session

3:00pm David Tobin, Duke University, USA Macrophage epithelial reprogramming underlies mycobacterial granuloma formation and promotes infection
3:20pm Lucia Du, University of Auckland, New Zealand Shedding light on immunity: The circadian-dependent response of innate immune cells during Salmonella infection
3:35pm Vahid Pazhakh, Monash University, Australia Spore shuttling between leukocytes in zebrafish fungal infection models is driven by components of the fungal cell wall
3:50pm Serge Mostoy, Imperial College London, United Kingdom New roles for the cytoskeleton in cell-autonomous immunity
4:05pm Pagan mTOR deficiency reveals an immunological trade-off in innate resistance to mycobacterial infection in vivo
4:20pm Thomas Boehm, Max Planck Institute, Freiburg, Germany Forward genetic screens in zebrafish to identify regulators of early T cell development: implications for human immunodeficiency disorders
4:40pm Flash Talks
5:00pm Poster Session 2
7:00pm Mentoring Meeting for Post Docs
7:00pm Mentoring Meeting for Grads

 6th October 2016, Thursday  

Time Session/Speaker Session Title
8:00am – 5:00pm Registration Open

Session 7: Skeletal Disorders– LKC Auditorium

9:00am Eric C. Liao, Harvard Medical School, USA Closing the Gap on Orofacial Cleft
9:20am Shannon Fischer, Boston University, USA Formation of skull bones and sutures in wild–type and mutant zebrafish
9:35am Liesbeth Gebuijs, Radboud UMC, Netherlands Investigating craniofacial disorders by targeting human candidate genes in zebrafish models.
9:50am Yann Gibert, Deakin University, Australia Additive Effects of the Endocannabinoid and Retinoic Acid Pathway in Bone Formation in Zebrafish
10:05am Monika Tomecka, Institute of Molecular and Cell Biology, USA Crush injury in zebrafish as a model to study human bone fracture repair.
10:20am Flash Talks
10:35am Christoph Winkler, Department of Biological Sciences, National University of Singapore, Singapore Pre-osteoblast activation during bone repair in a medaka osteoporosis model

Session 8: Cancer 2 – CSB Auditorium

9:00am Elizabeth Patton, MRC Institute, Edinburgh, United Kingdom The metastasis-associated Prl3 (Ptp4a3) phosphatase regulates the melanocyte stem cell lineage
9:20pm Yariv Houvras, Weill Cornell Medical College, USA A novel model of thyroid carcinoma in zebrafish reveals a genetic requirement for Twist expression during BRAF mediated transformation
9:35am Joan Heath, The Walter and Eliza Hall Institute of Medical Research, Australia Essential roles for minor class splicing in development and cancer
9:50am Richard White, Memorial Sloan Kettering Cancer Center, USA Microenvironment-derived factors drive metastases towards a differentiated cell state
10:05am Wei-Siang Liau, National University of Singapore, Cancer Science Institute, Singapore Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors Contributes to T-cell Leukemogenesis
10:20am Flash Talks
10:35am David Langenau, Harvard Medical School, USA TBD
10:55am Refreshment Break

Session 9: President’s Session

11:30am Jeroen den Hertog, Hubrecht Institute, Netherlands Protein-tyrosine phosphatase signaling in fin regeneration
11:45am Han Wang, Soochow University, China Integrating Human Clinical Data, Exome Sequencing, and High-throughput Zebrafish Mutagenesis for the Study of Rare Genetic Diseases
12:00pm Sudipto Roy, Institute of Molecular and Cell Biology, Singapore Mutations in DZIP1L, which encodes a ciliary transition zone protein, cause autosomal recessive polycystic kidney disease
12:15pm Bruno Reversade, Institute of Medical Biology (A*STAR), Singapore Arhinia: to Have, or Not to Have, a Nose
12:30pm Lunch and Poster Session 3
3:00pm – 6:00pm Research Interest Groups (RIG) Workshops
6:30pm Conference Dinner – Tamarind Hill

7th October 2016, Friday   

Time Session/Speaker Session Title
8:00am – 12:00pm Registration Open

Session 10: Neuro/Behaviour

9:00am Michael Brand, Biotechnology Center, Dresden University of Technology, Germany TBD
9:20am Eyleen Goh, Duke-NUS Medical School, Singapore Methyl-CpG binding protein 2 (Mecp2) Regulates Sensory Function through Enhancing Expression of Guidance Cues
9:35am Kochi Kawakami, National Institute of Genetics, Japan The zebrafish amygdala and hippocampus
9:50am Ivana Poparic, Kings College London, United Kingdom Zebrafish models of human eye movement disorders; the role of α2-chimaerin
10:05am Ajay Mathuru, Institute of Molecular and Cell Biology, Singapore Investigating the neurogenetics of addiction using zebrafish
10:20am Jiu-Lin Du, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China A dedicated retina-EmT-left habenula pathway controls light preference of larval zebrafish
10:45am Refreshment Break

Session 11: Toxicology

11:10am Deborah Kurrasch, University of Calgary, Canada The effects of environmental contaminants on developing zebrafish brains
11:30am Daniel Gorelick, University of Alabama at Birmingham, USA Estrogens regulate heart rate via the G protein-coupled estrogen receptor
11:45am Charles R. Tyler, University of Exeter, United Kingdom Transgenic Zebrafish and Endocrine Disruption Research
12:05pm Michelina Stoddard, Tri-Institutional MD-PhD Program, USA The Liver Inflammation Assay: A Novel Tool to Study the Inflammatory Effects of Drug-Induced Liver Injury
12:20pm Herman Spaink, Leiden University, Netherlands Zebrafish larvae as a model for toxicology studies: from high through-put drug screens to pharmacokinetic modelling
12:40pm ZDMS Annual General Meeting
1:30pm Lunch
2:30pm Sightseeing Tour to Botanical Gardens

*All names in italics refer to the invited speakers