The 9th Zebrafish Disease Models Conference Agenda

Venue: Marina Bay Sands

10 Bayfront Ave. Singapore, 018956

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4th October 2016, Tuesday

Time

Session/Speaker

Session Title

12:00pm – 6:00pm Registration Open
2:00pm

Welcome Remarks

Philip Ingham, Vice President of ZDMS and Chair of ZDM9

2:05pm

Introductions

James Amatruda, President of ZDMS

2:10pm

Opening Address

James Best, Dean, Lee Kong Chian School of Medicine

Session 1: Cancer 1

2:20pm Thomas Look, Dana Farber Cancer Institute, USA Molecular Pathogenesis and Drug Synergism in a Zebrafish Model of High Risk Neuroblastoma
2:40pm Shuning He, Dana Farber Cancer Institute, USA A zebrafish model of NF1- and PTEN-mutant melanomas that lack activating mutations of BRAF or NRAS
2:55pm Paul Martin, University of Bristol, United Kingdom Modelling cancer Inflammation and treatments including surgery and radiotherapy
3:15pm James Amatruda, UT Southwestern Medical Center, USA Expression of human CIC-DUX4 fusions in zebrafish recapitulates the spectrum of human CIC-rearranged cancers
3:30pm Leonard Zon, Children’s Hospital Boston, USA Neural crest progenitor identity is a key event in the initiation of melanoma and metastasis
3:50pm Refreshment Break
Session 2: Emerging Technologies
4:20pm Sabine Costagliola, ULB-IRIBHM, Belgium A CRISPR/Cas-based mutagenesis approach in zebrafish to delineate gene function underlying congenital hypothyroidism
4:35pm Christian Mosimann, University of Zurich, Switzerland Of crispant screens for congenital disease genes
4:50pm Farhad Imam, University of California, San Diego, USA Zebrafish at the Bedside: in vivo Validation of Human Disease Sequence Variants
5:05pm Flash Talks
5:30pm

Keynote Speaker:

Stuart Cook

Professor and Director, Programme in Cardiovascular & Metabolic Disorders, Duke-NUS Medical School, Director, National Heart Research Institute of Singapore

Professor of Clinical and Molecular Cardiology, Imperial College London, United Kingdom

6:30pm Welcome Reception

 5th October 2016, Wednesday 

Time Session/Speaker Session Title
8:00am – 5:00pm Registration Open

Session 3: Muscle and Cardiac – Concurrent Session

9:00am Peter Currie, ARMI, Monash University, Australia Cell cycle arrest regulates clonal drift of muscle stem cells during growth.
9:20am Ching Ling Ellen Lien, Children’s Hospital Los Angeles, USA Zebrafish model to study congenital coronary anomalies
9:35am Rebecca Richardson, University of Bristol, United Kingdom Specific macrophage populations are required for adult zebrafish cardiac regeneration
9:50am Alasdair Wood, ARMI, Monash University, Australia Evaluating Integrin-b1 as a Therapeutic Target for MDC1a
10:05am Inken Gisela Huttner, Victor Chang Cardiac Research Institute, Australia Assessment of cardiac function in adult zebrafish using high frequency echocardiography: validation and standardization of a novel protocol
10:20am Flash Talks
10:40am Jeroen Bakkers, The Hubrecht Institute, Netherlands Spatially resolved transcriptomics to identify regulators of heart regeneration.

Session 4: Hematology – Concurrent Session

9:00am Trista E. North, Harvard Medical School, USA

Distinct Roles for Matrix Metalloproteinase 2 (MMP2) and

MMP9 in Embryonic Hematopoietic Stem Cell Production

9:20pm Yoonsung Lee, University of California, San Diego, USA FACT component Supt16h regulates transcription of Notch elements to specify hematopoietic stem cells
9:35am Julie Perlin, Boston Children’s Hospital, USA Using genome-wide RNA tomography to dissect the hematopoietic stem cell niche in zebrafish
9:50am Valerie Wittamer, Universite Libre de Bruxelles, Belgium Insights into the Cellular and Molecular Mechanisms of Microglia Ontogeny
10:05am Martina Konantz, University Hospital Basel, Switzerland Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence
10:20am Flash Talks
10:40am Jill de Jong, The University of Chicago, USA Genomic and functional diversity of antigen processing and presentation genes in zebrafish
11:00am Refreshment Break
11:30am

Keynote Speaker:

John Mattick

Executive Director, The Garvan Institute of Medical Research, Australia

12:30pm Lunch and Poster Session 1

Session 5: GI and Metabolism – Concurrent Session

3:00pm Michael A. Pack, University of Pennsylvania, USA Variant redox and proteomic stress responses as risk factors for biliary disease
3:20pm Andrew Cox, Brigham and Women’s Hospital, Harvard Medical School, USA Yap regulates glucose uptake and the anabolic biosynthesis of nucleotides to support liver growth
3:35pm Yanmei Liu, Institute of Molecular Medicine, Peking University, China Glucose Activates Calcineurin/NFAT to Initiate and Drive the Heterogeneous Maturation of beta Cells In Vivo
3:50pm Wolfram Goessling, Harvard Medical School, USA Estrogen sensing in the liver by the G protein-coupled receptor GPER1 regulates PI3K/AKT and MTOR activity to control normal and malignant growth
4:05pm Shawn Burgess, National Human Genome Research Institute, USA Integrating Human Clinical Data, Exome Sequencing, and High-throughput Zebrafish Mutagenesis for the Study of Rare Genetic Diseases
4:20pm Kirsten Sadler Edepli, New York University Abu Dhabi, United Arab Emirates A potent cocktail: Arsenic synergizes with ethanol to cause liver disease in zebrafish
4:40pm Flash Talks

Session 6: Infection and Immunity – Concurrent Session

3:00pm David Tobin, Duke University, USA Macrophage epithelial reprogramming underlies mycobacterial granuloma formation and promotes infection
3:20pm Lucia Du, University of Auckland, New Zealand Shedding light on immunity: The circadian-dependent response of innate immune cells during Salmonella infection
3:35pm Vahid Pazhakh, Monash University, Australia Spore shuttling between leukocytes in zebrafish fungal infection models is driven by components of the fungal cell wall
3:50pm Serge Mostoy, Imperial College London, United Kingdom New roles for the cytoskeleton in cell-autonomous immunity
4:05pm Pagan mTOR deficiency reveals an immunological trade-off in innate resistance to mycobacterial infection in vivo
4:20pm Thomas Boehm, Max Planck Institute, Freiburg, Germany Forward genetic screens in zebrafish to identify regulators of early T cell development: implications for human immunodeficiency disorders
4:40pm Flash Talks
5:00pm Poster Session 2
7:00pm Mentoring Meeting for Post Docs
7:00pm Mentoring Meeting for Grads

 6th October 2016, Thursday  

Time Session/Speaker Session Title
8:00am – 5:00pm Registration Open

Session 7: Skeletal Disorders– LKC Auditorium

9:00am Eric C. Liao, Harvard Medical School, USA Closing the Gap on Orofacial Cleft
9:20am Shannon Fischer, Boston University, USA Formation of skull bones and sutures in wild–type and mutant zebrafish
9:35am Liesbeth Gebuijs, Radboud UMC, Netherlands Investigating craniofacial disorders by targeting human candidate genes in zebrafish models.
9:50am Yann Gibert, Deakin University, Australia Additive Effects of the Endocannabinoid and Retinoic Acid Pathway in Bone Formation in Zebrafish
10:05am Monika Tomecka, Institute of Molecular and Cell Biology, USA Crush injury in zebrafish as a model to study human bone fracture repair.
10:20am Flash Talks
10:35am Christoph Winkler, Department of Biological Sciences, National University of Singapore, Singapore Pre-osteoblast activation during bone repair in a medaka osteoporosis model

Session 8: Cancer 2 – CSB Auditorium

9:00am Elizabeth Patton, MRC Institute, Edinburgh, United Kingdom The metastasis-associated Prl3 (Ptp4a3) phosphatase regulates the melanocyte stem cell lineage
9:20pm Yariv Houvras, Weill Cornell Medical College, USA A novel model of thyroid carcinoma in zebrafish reveals a genetic requirement for Twist expression during BRAF mediated transformation
9:35am Joan Heath, The Walter and Eliza Hall Institute of Medical Research, Australia Essential roles for minor class splicing in development and cancer
9:50am Richard White, Memorial Sloan Kettering Cancer Center, USA Microenvironment-derived factors drive metastases towards a differentiated cell state
10:05am Wei-Siang Liau, National University of Singapore, Cancer Science Institute, Singapore Aberrant Activation of the GIMAP Enhancer by Oncogenic Transcription Factors Contributes to T-cell Leukemogenesis
10:20am Flash Talks
10:35am David Langenau, Harvard Medical School, USA TBD
10:55am Refreshment Break

Session 9: President’s Session

11:30am Jeroen den Hertog, Hubrecht Institute, Netherlands Protein-tyrosine phosphatase signaling in fin regeneration
11:45am Han Wang, Soochow University, China Integrating Human Clinical Data, Exome Sequencing, and High-throughput Zebrafish Mutagenesis for the Study of Rare Genetic Diseases
12:00pm Sudipto Roy, Institute of Molecular and Cell Biology, Singapore Mutations in DZIP1L, which encodes a ciliary transition zone protein, cause autosomal recessive polycystic kidney disease
12:15pm Bruno Reversade, Institute of Medical Biology (A*STAR), Singapore Arhinia: to Have, or Not to Have, a Nose
12:30pm Lunch and Poster Session 3
3:00pm – 6:00pm Research Interest Groups (RIG) Workshops
6:30pm Conference Dinner – Tamarind Hill

7th October 2016, Friday   

Time Session/Speaker Session Title
8:00am – 12:00pm Registration Open

Session 10: Neuro/Behaviour

9:00am Michael Brand, Biotechnology Center, Dresden University of Technology, Germany TBD
9:20am Eyleen Goh, Duke-NUS Medical School, Singapore Methyl-CpG binding protein 2 (Mecp2) Regulates Sensory Function through Enhancing Expression of Guidance Cues
9:35am Kochi Kawakami, National Institute of Genetics, Japan The zebrafish amygdala and hippocampus
9:50am Ivana Poparic, Kings College London, United Kingdom Zebrafish models of human eye movement disorders; the role of α2-chimaerin
10:05am Ajay Mathuru, Institute of Molecular and Cell Biology, Singapore Investigating the neurogenetics of addiction using zebrafish
10:20am Jiu-Lin Du, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China A dedicated retina-EmT-left habenula pathway controls light preference of larval zebrafish
10:45am Refreshment Break

Session 11: Toxicology

11:10am Deborah Kurrasch, University of Calgary, Canada The effects of environmental contaminants on developing zebrafish brains
11:30am Daniel Gorelick, University of Alabama at Birmingham, USA Estrogens regulate heart rate via the G protein-coupled estrogen receptor
11:45am Charles R. Tyler, University of Exeter, United Kingdom Transgenic Zebrafish and Endocrine Disruption Research
12:05pm Michelina Stoddard, Tri-Institutional MD-PhD Program, USA The Liver Inflammation Assay: A Novel Tool to Study the Inflammatory Effects of Drug-Induced Liver Injury
12:20pm Herman Spaink, Leiden University, Netherlands Zebrafish larvae as a model for toxicology studies: from high through-put drug screens to pharmacokinetic modelling
12:40pm ZDMS Annual General Meeting
1:30pm Lunch
2:30pm Sightseeing Tour to Botanical Gardens

*All names in italics refer to the invited speakers