News Updates

Keystone Review

  Keystone Symposium on DNA Methylation and Epigenomics – Zebrafish Highlights March 29 – April 3, 2015 Brandon KentGraduate student, Sadler and Walsh laboratories, Icahn School of Medicine at Mount Sinai, USA Heritable, covalent (“epigenetic”) modification of DNA and the core histone proteins is a central tenet vital to cellular specification, differentiation, and an organism’s development and… more

Zebrafish make their own sunscreen

Zebrafish make their own sunscreen Osborn, R.A., Almabruk, K.H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K.M., Karplus, P.A., Tanguay, R.L., Bakalinsky, A.T., Mahmud, T. (2015). De novo synthesis of a sunscreen compound in vertebrates. eLIFE. A compound known as gadusol is responsible for protecting many animals, like the zebrafish, from the sun’s harmful ultraviolet radiation, a… more

New zebrafish model should speed research on parasite that causes toxoplasmosis

New zebrafish model should speed research on parasite that causes toxoplasmosis Researchers at Oregon State University have found a method to speed the search for new therapies to treat toxoplasmosis – by successfully infecting zebrafish with Toxoplasma gondii. The findings were just published in the Journal of Fish Diseases, in work supported by the Tartar Foundation and the National… more

Murcia University honours Dr. Leonard Zon

Murcia University honours Dr. Leonard Zon Jorge Galindo-Villegas, Murcia University, Spain On April 21st, 2015, Dr. Len Zon, Director of the Stem Cell Program at Children’s Hospital Boston at Harvard Medical School (USA), was made Doctor Honoris Causa by Murcia University, Spain. The academic ceremony was presided over by the Honorable Rector Magnificus José Orihuela Calatayud and… more

Duke Study Uncovers Foundations of Heart Regeneration

Duke Study Uncovers Foundations of Heart Regeneration The outer layer of the zebrafish heart (shown in green) is regenerated rapidly after damage, covering the heart like a wave from the base of one chamber to the tip of the other. Researchers have discovered properties of this mysterious outer layer — known as the epicardium — that could… more

A new role for zebrafish: Larger scale gene function studies

A new role for zebrafish: Larger scale gene function studies NHGRI scientists are homing in on specific genes in zebrafish to help them better understand the function of genes in people. Read full article here A relatively new method of targeting specific DNA sequences in zebrafish could dramatically accelerate the discovery of gene function and the identification… more

How Blood Stem Cells Take Root in the Body

Live imaging captures how blood stem cells take root in the body Fliesler, N. (2015) Live imaging captures how blood stem cells take root in the body. Vector – Boston Children’s Hospital. Read full article here For years, the lab of Leonard Zon, MD, director of the Stem Cell Research Program at Boston Children’s Hospital, has sought… more

Spotlight on Zebrafish

Spotlight on Zebrafish: Translational Impact Amatruda, J.F. Dhillon, P., Patton, E. and Ramakrishnan L. (2014) Spotlight on Zebrafish: Translational Impact. Dis. Model. Mech. 7, 731733 Read Full Article Here In recent years, the zebrafish has emerged as an increasingly prominent model in biomedical research. To showcase the translational impact of the model across multiple disease areas, Disease… more

Unfolded Protein Response

Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish Vacaru A.M., Di Narzo, A.F., Howarth, D.L., Tsedensodnom, O., Imrie, D., Cinaroglu, A., Amin, S., Hao, K., and Sadler, K.C. (2014) Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Dis. Model. Mech. 7, 823-835 Read… more